The Brain at High Altitude: From Molecular Signaling to Cognitive Performance-Reference-Cited by-同舟云学术

The Brain at High Altitude: From Molecular Signaling to Cognitive Performance

Published:2023-06-15 Issue:12 Volume:24 Page:10179
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Aboouf Mostafa A.¹²³^ORCID,Thiersch Markus¹³^ORCID,Soliz Jorge⁴,Gassmann Max¹³^ORCID,Schneider Gasser Edith M.¹⁴⁵^ORCID

Affiliation:

1. Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zürich, 8057 Zurich, Switzerland

2. Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt

3. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland

4. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Faculty of Medicine, Université Laval, Québec, QC G1V 4G5, Canada

5. Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland

Abstract

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims to summarize the cellular, metabolic, and functional alterations in the brain at HA with a focus on the role of hypoxia-inducible factors in controlling the hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, and plasticity.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/12/10179/pdf

Reference271 articles.

1. Incidence of major depressive episode correlates with elevation of substate region of residence;DelMastro;J. Affect. Disord.,2011

2. Altitude and risk of depression and anxiety: Findings from the intern health study;Kious;Int. Rev. Psychiatry,2019

3. High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling;Bengoetxea;Front. Cell. Neurosci.,2018

4. Neuropsychological functioning associated with high-altitude exposure;Garrido;Neuropsychol. Rev.,2004

5. Long-Term Exposure to High Altitude Affects Voluntary Spatial Attention at Early and Late Processing Stages;Wang;Sci. Rep.,2014

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cognitive effects of altitude exposure;Journal of Travel Medicine;2024-08-22

2. The effects of real vs simulated high altitude on associative memory for emotional stimuli;Physiology & Behavior;2024-08

3. Reduced Violence-Related Burden and Mortality at Higher Altitudes: Examining the Association between High Altitude Living and Homicide Rates in Ecuador;High Altitude Medicine & Biology;2024-06-07

4. The Hypoxia Response Pathway: A Potential Intervention Target in Parkinson's Disease?;Movement Disorders;2023-12-23

5. Mechanisms underlying the health benefits of intermittent hypoxia conditioning;The Journal of Physiology;2023-10-20