Affiliation:
1. School of Basic Medical Science, Henan University, Kaifeng 475004, China
2. School of Clinical Medicine, Henan University, Kaifeng 475004, China
Abstract
Ferroptosis, characterized by glutamate overload, glutathione depletion, and cysteine/cystine deprivation during iron- and oxidative-damage-dependent cell death, is a particular mode of regulated cell death. It is expected to effectively treat cancer through its tumor-suppressor function, as mitochondria are the intracellular energy factory and a binding site of reactive oxygen species production, closely related to ferroptosis. This review summarizes relevant research on the mechanisms of ferroptosis, highlights mitochondria’s role in it, and collects and classifies the inducers of ferroptosis. A deeper understanding of the relationship between ferroptosis and mitochondrial function may provide new strategies for tumor treatment and drug development based on ferroptosis.
Funder
National Natural Science Foundation of China
Key R&D and Promotion Projects in Henan Province
Key Scientific Research Projects of Colleges and Universities in Henan Province
Kaifeng Science and Technology Development Plan
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
10 articles.
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