Immunomodulatory Role of Interferons in Viral and Bacterial Infections

Author:

Mertowska Paulina1ORCID,Smolak Konrad1,Mertowski Sebastian1ORCID,Grywalska Ewelina1ORCID

Affiliation:

1. Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland

Abstract

Interferons are a group of immunomodulatory substances produced by the human immune system in response to the presence of pathogens, especially during viral and bacterial infections. Their remarkably diverse mechanisms of action help the immune system fight infections by activating hundreds of genes involved in signal transduction pathways. In this review, we focus on discussing the interplay between the IFN system and seven medically important and challenging viruses (herpes simplex virus (HSV), influenza, hepatitis C virus (HCV), lymphocytic choriomeningitis virus (LCMV), human immunodeficiency virus (HIV), Epstein–Barr virus (EBV), and SARS-CoV coronavirus) to highlight the diversity of viral strategies. In addition, the available data also suggest that IFNs play an important role in the course of bacterial infections. Research is currently underway to identify and elucidate the exact role of specific genes and effector pathways in generating the antimicrobial response mediated by IFNs. Despite the numerous studies on the role of interferons in antimicrobial responses, many interdisciplinary studies are still needed to understand and optimize their use in personalized therapeutics.

Funder

Polish National Science Centre

Medical University of Lublin

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference294 articles.

1. Interferons at age 50: Past, Current and Future Impact on Biomedicine;Borden;Nat. Rev. Drug Discov.,2007

2. Interferon-inducible antiviral effectors;Sadler;Nat. Rev. Immunol.,2008

3. Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history;Dai;Cytokine Growth Factor Rev.,2008

4. Interferon-γ: A historical perspective;Billiau;Cytokine Growth Factor Rev.,2009

5. The Interferon System: An Overview;Ravera;Eur. J. Paediatric Neurol.,2002

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