Pathognomonic Signs in Pancreatic Cystic Lesions: What Gastroenterologists and Involved Clinicians Need to Know

Author:

Martino Alberto1ORCID,Barresi Luca2,Zito Francesco Paolo1,Amata Michele3ORCID,Fiorentino Roberto4,Campione Severo5,Iacobelli Alessandro5,Crolla Enrico6ORCID,Di Mitri Roberto3,Molino Carlo6,Di Serafino Marco7,Lombardi Giovanni1

Affiliation:

1. Department of Gastroenterology and Digestive Endoscopy, AORN “Antonio Cardarelli”, 80131 Napoli, Italy

2. Pancreas Unit, IRCCS-ISMETT (Mediterranean Institute for Transplantation and Highly Specialized Therapies), 90127 Palermo, Italy

3. Gastroenterology and Endoscopy Unit, ARNAS Civico—Di Cristina—Benfratelli Hospital, 90127 Palermo, Italy

4. Department of Oncology, AORN “Antonio Cardarelli”, 80131 Napoli, Italy

5. Department of Pathology, AORN “Antonio Cardarelli”, 80131 Napoli, Italy

6. Department of Oncological Surgery, AORN “Antonio Cardarelli”, 80131 Napoli, Italy

7. Department of General and Emergency Radiology, AORN “Antonio Cardarelli”, 80131 Napoli, Italy

Abstract

Pancreatic cystic lesions (PCLs) have been increasingly identified in recent years, encompassing a wide spectrum ranging from benign non-evolutive to malignant invasive lesions. Despite various clinical, laboratory, imaging, endoscopic ultrasound, and cytohistological features that may aid clinicians in the complex differential diagnosis of PCLs, only a few pathognomic signs distinctive to specific PCLs have been identified. Although rarely encountered, their proper recognition is crucial for the appropriate management of PCLs. The aim of our review is to extensively discuss and illustrate pathognomic signs in the setting of PCLs.

Publisher

MDPI AG

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