Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study-Reference-Cited by-同舟云学术

Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study

Published:2024-01-04 Issue:1 Volume:14 Page:86
ISSN:2075-1729
Container-title:Life
language:en
Short-container-title:Life

Author:

Caturano Alfredo¹²^ORCID,Galiero Raffaele¹^ORCID,Vetrano Erica¹,Medicamento Giulia¹,Alfano Maria¹,Beccia Domenico¹,Brin Chiara¹^ORCID,Colantuoni Sara¹,Di Salvo Jessica¹,Epifani Raffaella¹,Nevola Riccardo¹³^ORCID,Marfella Raffaele¹^ORCID,Sardu Celestino¹^ORCID,Coppola Carmine⁴,Scarano Ferdinando⁵,Maggi Paolo⁶^ORCID,Calabrese Cecilia⁷^ORCID,De Lucia Sposito Pellegrino⁸,Rescigno Carolina⁹,Sbreglia Costanza¹⁰,Fraganza Fiorentino¹¹,Parrella Roberto¹²,Romano Annamaria¹³,Calabria Giosuele¹⁴,Polverino Benedetto¹⁵,Pagano Antonio¹⁶,Numis Fabio Giuliano¹⁶,Bologna Carolina¹⁷^ORCID,Nunziata Mariagrazia¹⁸,Esposito Vincenzo¹⁹,Coppola Nicola²⁰^ORCID,Maturo Nicola²¹,Nasti Rodolfo²²,Di Micco Pierpaolo²³^ORCID,Perrella Alessandro²⁴^ORCID,Adinolfi Luigi Elio¹^ORCID,Di Domenico Marina²⁵,Monda Marcellino²^ORCID,Russo Vincenzo²⁶²⁷^ORCID,Ruggiero Roberto²⁸,Docimo Giovanni²⁹,Rinaldi Luca³⁰^ORCID,Sasso Ferdinando Carlo¹^ORCID

Affiliation:

1. Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Piazza L. Miraglia 2, 80138 Naples, Italy

2. Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

3. Ospedale Evangelico Betania, 80147 Naples, Italy

4. Hepatology Unit, Internal Medicine, Area Stabiese Hospital, 80053 Naples, Italy

5. COVID Center “S. Anna e SS. Madonna della Neve” Hospital, 80042 Boscotrecase, Italy

6. U.O.C. Infectious and Tropical Diseases, S. Anna e S. Sebastiano Hospital, 81100 Caserta, Italy

7. U.O.C. Pneumologia Vanvitelli, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, AORN Ospedali dei Colli, Via Leonardo Bianchi, 80131 Naples, Italy

8. COVID Center, Maddaloni Hospital, 80124 Maddaloni, Italy

9. U.O.C. Infectious Diseases and Neurology, Cotugno Hospital, 80131 Naples, Italy

10. U.O.C. Infectious Diseases of the Elderly, Cotugno Hospital, 80131 Naples, Italy

11. U.O.C. Anestesia and Intensive Care Unit, Cotugno Hospital, 80131 Naples, Italy

12. U.O.C. Respiratory Infectious Diseases, Cotugno Hospital, 80131 Naples, Italy

13. U.O.C. Pneumology, Moscati Hospital, 83100 Avellino, Italy

14. IXth Division of Infectious Diseases and Interventional Ultrasound, Cotugno Hospital, 80131 Naples, Italy

15. “Giovanni da Procida” Hospital, 84126 Salerno, Italy

16. Emergency and Acceptance Unit, “Santa Maria delle Grazie” Hospital, 80078 Pozzuoli, Italy

17. Internal Medicine Unit, Ospedale Del Mare, 80147 Naples, Italy

18. U.O.C. Internal Medicine, Moscati Hospital, 83100 Avellino, Italy

19. IVth Division of Immunodeficiency and Gender Infectious Diseases, Cotugno Hospital, 80131 Naples, Italy

20. COVID Center, Department of Mental Health and Public Medicine, A.O.U. Vanvitelli, 80131 Naples, Italy

21. U.O.S.D. Infectious Diseases Emergency and Acceptance, Cotugno Hospital, 80131 Naples, Italy

22. Emergency Division, A.O.R.N. “Antonio Cardarelli”, 80131 Naples, Italy

23. Department of Internal Medicine, Fatebenefratelli Hospital of Naples, 80123 Naples, Italy

24. Task Force COVID-19 Regione Campania, 80131 Napoli, Italy

25. Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

26. Department of Biology, College of Science and Technology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA

27. Division of Cardiology, Department of Medical Translational Sciences, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

28. Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

29. Unit of Thyroid Surgery, Department of Medical and Advanced Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

30. Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, 86100 Campobasso, Italy

Abstract

Background and Aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact of acute kidney injury (AKI) on the in-hospital mortality in octogenarian patients with COVID-19. Methods: This is a prospective observational cohort study, which involved 23 COVID-19 hospital units in the Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. Only patients aged ≥80 years were deemed eligible for the study. Results: 197 patients were included in the study (median age 83.0 [82.0–87.0] years; 51.5% men), with a median duration of hospitalization of 15.0 [8.0–25.0] days. From the multivariable Cox regression analysis, after the application of Šidák correction, only the respiratory rate (HR 1.09, 95% CI: 1.04 to 1.14; p < 0.001) and AKI development (HR: 3.40, 95% CI: 1.80 to 6.40; p < 0.001) were independently associated with the primary outcome. Moreover, the Kaplan–Meier analysis showed a significantly different risk of in-hospital mortality between patients with and without AKI (log-rank: <0.0001). Conclusions: In our investigation, we identified a significant association between AKI and mortality rates among octogenarian patients admitted for COVID-19. These findings raise notable concerns and emphasize the imperative for vigilant monitoring of this demographic cohort.

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Link

https://www.mdpi.com/2075-1729/14/1/86/pdf

Reference41 articles.

1. Sharma, A., Ahmad Farouk, I., and Lal, S.K. (2021). COVID-19: A Review on the Novel Coronavirus Disease Evolution, Transmission, Detection, Control and Prevention. Viruses, 13.

2. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19;Valdenassi;Eur. Rev. Med. Pharmacol. Sci.,2020

3. (2023, November 25). World Health Organization. Available online: https://covid19.who.int/.

4. Vianello, A., De Vita, N., Scotti, L., Guarnieri, G., Confalonieri, M., Bonato, V., Molena, B., Maestrone, C., Airoldi, G., and Olivieri, C. (2022). Clinical Outcomes in Patients Aged 80 Years or Older Receiving Non-Invasive Respiratory Support for Hypoxemic Acute Respiratory Failure Consequent to COVID-19. J. Clin. Med., 11.

5. Galiero, R., Pafundi, P.C., Simeon, V., Rinaldi, L., Perrella, A., Vetrano, E., Caturano, A., Alfano, M., Beccia, D., and Nevola, R. (2020). Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study. PLoS ONE, 15.