Abstract
Dendritic cells (DCs) are a type of cells derived from bone marrow that represent 1% or less of the total hematopoietic cells of any lymphoid organ or of the total cell count of the blood or epithelia. Dendritic cells comprise a heterogeneous population of cells localized in different tissues where they act as sentinels continuously capturing antigens to present them to T cells. Dendritic cells are uniquely capable of attracting and activating naïve CD4+ and CD8+ T cells to initiate and modulate primary immune responses. They have the ability to coordinate tolerance or immunity depending on their activation status, which is why they are also considered as the orchestrating cells of the immune response. The purpose of this review is to provide a general overview of the current knowledge on ontogeny and subsets of human dendritic cells as well as their function and different biological roles.
Subject
General Economics, Econometrics and Finance
Reference133 articles.
1. The distribution of Langerhans cells within the human hair follicle, and some observations on its staining properties with gold chloride;Breathnach;J. Anat.,1963
2. IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
3. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice.
4. Dendritic cells: From the fabric of immunology;Steinman;Clin. Investig. Med.,2004
5. Studies of the cell surface of mouse dendritic cells and other leukocytes
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