Effect of Vitamin D Supplementation on the Cerebral Placental Ratio in Pregnancy Complicated with Early Fetal Growth Restriction

Author:

Jakubiec-Wisniewska Karolina,Huras Hubert,Kolak MagdalenaORCID

Abstract

Fetal growth restriction (FGR) is a complication of pregnancy connected with increased risk of intrauterine fetal demise. To increase the diagnostic accuracy, the cerebral placental ratio (CPR) is used. Vitamin D may play a role in the regulation of vascular flow in the fetus. The aim is to assess the relationship between CPR and vitamin D supplementation in fetuses with early FGR. It is a prospective cohort study. Pregnant females were divided into groups with 2000 IU and <500 IU of vitamin D. Both groups were observed for 14 days; USG was performed three times with one-week intervals. EFW and CPR were measured. Absolute CPR values were initially observed to differ significantly (p = 0.0032). Measurements on the seventh day of observation indicated that CPR was significantly higher (p = 0.0455) in fetuses of patients receiving vitamin D at a dose of 2000 IU 1.75 (IQR: 1.47; 2.06) vs. <500 IU group 1.55 (IQR: 1.04; 1.52). Similarly, on day 14: (p < 0.0001)—2.39 (IQR: 1.82; 2.69) vs. 1.21 (IQR: 0.98; 1.52). Supplementation with vitamin D at a dose of 2000 IU may have an influence on the increase in the CPR in fetuses with early FGR.

Publisher

MDPI AG

Subject

General Medicine

Reference43 articles.

1. Nieprawidłowe wzrastanie płodu (hipotrofia i hipertrofia);Kamiński,2010

2. Położnictwo. Tom II;Bręborowicz,2012

3. GROWTH OF THE HUMAN FETUS

4. The Investigation and Management of the Small–for–Gestational–Age Fetus,2014

5. Chromogranin A demonstrates higher expression in preeclamptic placentas than in normal pregnancy

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