Candida auris in Intensive Care Setting: The First Case Reported in Portugal-Reference-Cited by-同舟云学术

Candida auris in Intensive Care Setting: The First Case Reported in Portugal

Published:2023-08-09 Issue:8 Volume:9 Page:837
ISSN:2309-608X
Container-title:Journal of Fungi
language:en
Short-container-title:JoF

Author:

Henriques João¹,Mixão Verónica²^ORCID,Cabrita Joana¹,Duarte Tiago Isidoro¹^ORCID,Sequeira Tânia¹,Cardoso Sofia¹,Germano Nuno¹,Dias Liliana³,Bento Luís¹^ORCID,Duarte Sílvia⁴^ORCID,Veríssimo Cristina⁵^ORCID,Gomes João Paulo²⁶^ORCID,Sabino Raquel⁵⁷⁸^ORCID

Affiliation:

1. Intensive Care Medicine Department, Centro Hospitalar Universitário Lisboa Central, 1150-199 Lisbon, Portugal

2. Genomics and Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal

3. Infection Prevention and Control and Antimicrobial Stewardship, Centro Hospitalar Universitário Lisboa Central, 1150-199 Lisbon, Portugal

4. Innovation and Technology Unit, Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal

5. Reference Unit for Parasitic and Fungal Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal

6. Faculty of Veterinary Medicine, University of Lisbon, Av. Universidade Técnica, 1300-477 Lisbon, Portugal

7. Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal

8. Laboratório Associado TERRA–Laboratório para o Uso Sustentável da Terra e dos Serviços dos Ecossistemas, Instituto Superior de Agronomia, Tapada da Ajuda, 1349-017 Lisbon, Portugal

Abstract

Candida auris is an opportunistic human pathogen that has rapidly spread to multiple countries and continents and has been associated with a high number of nosocomial outbreaks. Herein, we report the first case of C. auris in Portugal, which was associated with a patient transferred from Angola to an ICU in Portugal for liver transplantation after a SARS-CoV-2 infection. C. auris was isolated during the course of bronchoalveolar lavage, and it was subjected to antifungal susceptibility testing and whole-genome sequence analysis. This isolate presents low susceptibility to azoles and belongs to the genetic clade III with a phylogenetic placement close to African isolates. Although clade III has already been reported in Europe, taking into account the patient’s clinical history, we cannot discard the possibility that the patient’s colonization/infection occurred in Angola, prior to admission in the Portuguese hospital. Considering that C. auris is a fungal pathogen referenced by WHO as a critical priority, this case reinforces the need for continuous surveillance in a hospital setting.

Funder

European Union EU4Health Programme

Foundation for Science and Technology (FCT), I.P.

Publisher

MDPI AG

Subject

Plant Science,Ecology, Evolution, Behavior and Systematics,Microbiology (medical)

Link

https://www.mdpi.com/2309-608X/9/8/837/pdf

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5. Increasing number of cases and outbreaks caused by Candida auris in the EU/EEA, 2020 to 2021;Kohlenberg;Eurosurveillance,2022