Affiliation:
1. National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan
2. S.D. Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan
3. Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana 010000, Kazakhstan
Abstract
Age-related obesity significantly increases the risk of chronic diseases such as type 2 diabetes, cardiovascular diseases, hypertension, and certain cancers. The insulin–leptin axis is crucial in understanding metabolic disturbances associated with age-related obesity. Rho GTPase Cdc42 is a member of the Rho family of GTPases that participates in many cellular processes including, but not limited to, regulation of actin cytoskeleton, vesicle trafficking, cell polarity, morphology, proliferation, motility, and migration. Cdc42 functions as an integral part of regulating insulin secretion and aging. Some novel roles for Cdc42 have also been recently identified in maintaining glucose metabolism, where Cdc42 is involved in controlling blood glucose levels in metabolically active tissues, including skeletal muscle, adipose tissue, pancreas, etc., which puts this protein in line with other critical regulators of glucose metabolism. Importantly, Cdc42 plays a vital role in cellular processes associated with the insulin and leptin signaling pathways, which are integral elements involved in obesity development if misregulated. Additionally, a change in Cdc42 activity may affect senescence, thus contributing to disorders associated with aging. This review explores the complex relationships among age-associated obesity, the insulin–leptin axis, and the Cdc42 signaling pathway. This article sheds light on the vast molecular web that supports metabolic dysregulation in aging people. In addition, it also discusses the potential therapeutic implications of the Cdc42 pathway to mitigate obesity since some new data suggest that inhibition of Cdc42 using antidiabetic drugs or antioxidants may promote weight loss in overweight or obese patients.
Funder
The Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan
Subject
Food Science,Nutrition and Dietetics
Reference325 articles.
1. World Health Organization (2023, January 23). Obesity and Overweight. Available online: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
2. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the Global Burden of Disease Study 2013;Ng;Lancet,2014
3. Obesity: Global epidemiology and pathogenesis;Nat. Rev. Endocrinol.,2019
4. Age, period and cohort effects on body mass index in New Zealand, 1997–2038;Wilson;Aust. N. Z. J. Public Health,2018
5. Age, period and birth cohort effects on prevalence of overweight and obesity in Australian adults from 1990 to 2000;Chey;Eur. J. Clin. Nutr.,2008
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