Abstract
Alzheimer’s disease is investigated using a thermodynamic approach based on ion fluxes across the neuronal membrane. Our study indicates that the onset of Alzheimer’s may be aided by a hyperpolarization of this membrane, because hyperpolarization-activated cyclic nucleotide gated HCN channels 1–4 conduct inward, with the consequence of depolarising Na+/K+ currents which in turn impacts synaptic transmission and reduces plasticity.
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
Cited by
2 articles.
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