Propranolol Hydrochloride Psychiatric Effectiveness and Oxidative Stress: An Update

Author:

Serreau Raphaël12ORCID,Amirouche Ammar1,Benyamina Amine1,Berteina-Raboin Sabine3ORCID

Affiliation:

1. Unité de Recherche Psychiatrie-Comorbidités-Addictions (PSYCOMadd), APHP Université Paris Saclay, Hôpital Paul-Brousse, 12 Avenue Paul Vaillant Couturier, 94804 Villejuif, France

2. Addictologie EPSM Georges DAUMEZON, GHT Loiret, 1 Route de Chanteau, 45400 Fleury les Aubrais, France

3. Institut de Chimie Organique et Analytique (ICOA), Université d’Orléans, UMR-CNRS 7311, BP 6759, Rue de Chartres, 45067 Orléans, France

Abstract

In this review, in addition to the potential cardiovascular applications of β-blockers and, more specifically, propranolol, we wanted to list the more recent applications in psychiatry as well as current knowledge on the impact of oxidative stress on propranolol hydrochloride and the oxidative stress that could be limited by the latter. In fact, a number of studies show that this molecule is modified by oxidative stress but is also able to limit it. Mention is also made to studies on the increasingly important problem of eliminating drug waste and its impact on the environment, particularly the marine environment. Given the increase in the consumption of medicines, more rigorous waste management is needed to avoid impacting biodiversity.

Publisher

MDPI AG

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