Inverse Association of Plasma Vanadium Concentrations with Gestational Diabetes Mellitus

Author:

Li Xiaoqin,Zhu Yalun,Yin Jiawei,Li Ben,Li Peiyun,Cao Benfeng,Wang QiangORCID,Xu Jian,Liu LiegangORCID

Abstract

Vanadium compounds were identified to be beneficial for the control of glucose homeostasis. We aimed to explore the association of plasma vanadium (V) with gestational diabetes mellitus (GDM). We performed a case-control study including 252 newly diagnosed GDM cases and 252 controls matched by age, parity, and gestational age. Fasting blood samples were collected from each participant at GDM screening (≥24 weeks of gestation). The plasma concentrations of V were determined utilizing inductively coupled plasma mass spectrometry. Plasma V levels were significantly lower in the GDM group than those in the control group (p < 0.001). The adjusted OR (95% CI) of GDM comparing the highest V tertile with the lowest tertile was 0.35 (0.20–0.61). According to the cubic spline model, the relation between plasma V and odds of GDM was potentially nonlinear (p < 0.001). Moreover, plasma V was negatively correlated with 1-h post-glucose load, 2-h post-glucose load, and lipid metabolism indices (all p < 0.05). The present study indicates an inverse association of plasma V with GDM. Further prospective cohort studies are required to validate our results.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Young Scientists Fund of the National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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