Maternal Risk Factors and Their Effect on Outcome and Procedure-Related Complications in Cordocentesis: A Multicenter Retrospective Study

Author:

Kosian Philipp1ORCID,Gloning Karl-Philipp2,Germer Ute3,Strizek Brigitte1ORCID,Berg Christoph4,Gembruch Ulrich1ORCID,Geipel Annegret1

Affiliation:

1. Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany

2. Pränatal-Medizin München, 80639 Munich, Germany

3. Department of Prenatal Medicine, St. Josef Hospital, 93053 Regensburg, Germany

4. Division of Prenatal Medicine and Gynecologic Sonography, Department of Obstetrics and Gynecology, University of Cologne, 50931 Cologne, Germany

Abstract

Background: Cordocentesis is used in clinical situations in which lower-risk diagnostic procedures do not deliver the desired results. The aim of this study was to evaluate the risk for procedure-related complications and fetal loss in correlation to maternal risk factors. Methods: This is a multicenter retrospective study investigating the complications, risk factors and perinatal outcome of diagnostic cordocentesis between 1998 and 2019 in three different centers. Results: A total of 1806 cordocenteses were performed and procedure-related complications (IUFD within 48 h, contractions, bradycardia, unsuccessful puncture, chorioamniotic separation) were noted in 1.6% of cases. Fetuses with chromosomal aberrations, intrauterine growth restriction and hydropic fetuses had a significantly higher rate of fetal loss compared to other indications. Fetal blood sampling (FBS) performed before 17+0 weeks of gestation was associated with a higher risk of procedure-related complications. Maternal BMI ≥ 40 increased the risk for fetal loss, whereas maternal age, number of previous miscarriages, number of previous abortions, history of vaginal bleeding or nicotine abuse did not affect the risk for complications or overall fetal loss rate. Conclusions: In the hands of experienced operators, FBS is a safe way to further fetal diagnostics, and the risk of complications is low.

Publisher

MDPI AG

Subject

General Medicine

Reference19 articles.

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2. A Rare and Challenging Case of Refractory Fetal Supraventricular Tachycardia;Celentano;Cureus,2022

3. Intrahepatic vein for fetal blood sampling: One center’s experience;Holcroft;Am. J. Obstet. Gynecol.,2008

4. Intrahepatic vein fetal blood sampling: Current role in prenatal diagnosis;Chinnaiya;J. Obstet. Gynaecol. Res.,1998

5. Effect of placenta penetration during cordocentesis at mid-pregnancy on fetal outcomes;Boupaijit;Prenat. Diagn.,2012

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