Bone Metastasis Detection in the Chest and Pelvis from a Whole-Body Bone Scan Using Deep Learning and a Small Dataset

Author:

Cheng Da-ChuanORCID,Liu Chia-Chuan,Hsieh Te-Chun,Yen Kuo-Yang,Kao Chia-HungORCID

Abstract

The aim of this study was to establish an early diagnostic system for the identification of the bone metastasis of prostate cancer in whole-body bone scan images by using a deep convolutional neural network (D-CNN). The developed system exhibited satisfactory performance for a small dataset containing 205 cases, 100 of which were of bone metastasis. The sensitivity and precision for bone metastasis detection and classification in the chest were 0.82 ± 0.08 and 0.70 ± 0.11, respectively. The sensitivity and specificity for bone metastasis classification in the pelvis were 0.87 ± 0.12 and 0.81 ± 0.11, respectively. We propose the use of hard example mining for increasing the sensitivity and precision of the chest D-CNN. The developed system has the potential to provide a prediagnostic report for physicians’ final decisions.

Funder

Ministry of Science and Technology, Taiwan

China Medical University, Taiwan

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Computer Networks and Communications,Hardware and Architecture,Signal Processing,Control and Systems Engineering

Reference20 articles.

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