An Effective Deep Learning-Based Architecture for Prediction of N7-Methylguanosine Sites in Health Systems

Abstract

N7-methylguanosine (m7G) is one of the most important epigenetic modifications found in rRNA, mRNA, and tRNA, and performs a promising role in gene expression regulation. Owing to its significance, well-equipped traditional laboratory-based techniques have been performed for the identification of N7-methylguanosine (m7G). Consequently, these approaches were found to be time-consuming and cost-ineffective. To move on from these traditional approaches to predict N7-methylguanosine sites with high precision, the concept of artificial intelligence has been adopted. In this study, an intelligent computational model called N7-methylguanosine-Long short-term memory (m7G-LSTM) is introduced for the prediction of N7-methylguanosine sites. One-hot encoding and word2vec feature schemes are used to express the biological sequences while the LSTM and CNN algorithms have been employed for classification. The proposed “m7G-LSTM” model obtained an accuracy value of 95.95%, a specificity value of 95.94%, a sensitivity value of 95.97%, and Matthew’s correlation coefficient (MCC) value of 0.919. The proposed predictive m7G-LSTM model has significantly achieved better outcomes than previous models in terms of all evaluation parameters. The proposed m7G-LSTM computational system aims to support the drug industry and help researchers in the fields of bioinformatics to enhance innovation for the prediction of the behavior of N7-methylguanosine sites.