Abstract
After SARS-CoV-2 infection, the molecular phenoreversion of the immunological response and its associated metabolic dysregulation are required for a full recovery of the patient. This process is patient-dependent due to the manifold possibilities induced by virus severity, its phylogenic evolution and the vaccination status of the population. We have here investigated the natural history of COVID-19 disease at the molecular level, characterizing the metabolic and immunological phenoreversion over time in large cohorts of hospitalized severe patients (n = 886) and non-hospitalized recovered patients that self-reported having passed the disease (n = 513). Non-hospitalized recovered patients do not show any metabolic fingerprint associated with the disease or immune alterations. Acute patients are characterized by the metabolic and lipidomic dysregulation that accompanies the exacerbated immunological response, resulting in a slow recovery time with a maximum probability of around 62 days. As a manifestation of the heterogeneity in the metabolic phenoreversion, age and severity become factors that modulate their normalization time which, in turn, correlates with changes in the atherogenesis-associated chemokine MCP-1. Our results are consistent with a model where the slow metabolic normalization in acute patients results in enhanced atherosclerotic risk, in line with the recent observation of an elevated number of cardiovascular episodes found in post-COVID-19 cohorts.
Funder
the SPRI I + D COVID-19 fund
BIOEF EITB Maratoia
the European Research Council (ERC)
The Spinnaker Health Research Foundation
The McCusker Foundation
The Western Australian State Government
MRFF
the UK MRC
the Department of Jobs, Tourism, Science and Innovation
Government of Western Australian Premier’s Fellowship
ARC Laureate Fellowship
Western Australian Covid Research Response team
Ministerio de Ciencia, Tecnología e Innovación
Ministerio de Educación Nacional
Ministerio de Industria, Comercio y Turismo
Colombia Científica para la Financiación
World Bank
Vicerrectoría de Investigaciones, Pontificia Universidad Javeriana, Bogotá, Colombia
Subject
Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism
Cited by
6 articles.
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