The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study

Author:

Bagalagel Alaa A.,El-hawary Seham S.,Alaaeldin RaniaORCID,Elmaidomy Abeer H.,Altemani Faisal H.ORCID,Waggas Dania S.ORCID,Algehainy Naseh A.,Saeedi Nizar H.ORCID,Alsenani FaisalORCID,Mokhtar Fatma A.ORCID,Elrehany Mahmoud A.,Al-Sanea Mohammad M.ORCID,Abdelmohsen Usama RamadanORCID

Abstract

LC-HRESIMS metabolomic profiling of Olea europaea L. cv. Picual (OEP) (Saudi Arabian olive cultivar, F. Oleacea) revealed 18 compounds. Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer’s disease, it was possible to identify the VEGFA, AChE, and DRD2 genes as the top correlated genes to Alzheimer’s disease with 8, 8, and 6 interactions in the same order. The mechanism of action on cellular components, biological processes, and molecular functions was determined by gene enrichment analysis. A biological pathway comparison revealed 13 shared pathways between the identified genes and Alzheimer protein genes (beta-amyloid band tau proteins). The suggested extract’s anti-Alzheimer potential in silico screening was confirmed through in vivo investigation in regressing the neurodegenerative features of Alzheimer’s dementia in an aluminum-intoxicated rat model (protective and therapeutic effects, 100 mg/kg b.w.). In vivo results suggested that OEP extract significantly improved Alzheimer’s rats, which was indicated by the crude extract’s ability to improve T-maze performance; lower elevated serum levels of AChE, AB peptide, and Ph/T ratio; and normalize the reduced level of TAC during the study. The results presented in this study may provide potential dietary supplements for the management of Alzheimer’s disease.

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

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