Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans

Author:

Rivas-Tumanyan SonaORCID,Pacheco Lorena S.ORCID,Haslam Danielle E.ORCID,Liang Liming,Tucker Katherine L.ORCID,Joshipura Kaumudi J.,Bhupathiraju Shilpa N.

Abstract

We assessed longitudinal associations between plasma metabolites, their network-derived clusters, and type 2 diabetes (T2D) progression in Puerto Rican adults, a high-risk Hispanic subgroup with established health disparities. We used data from 1221 participants free of T2D and aged 40–75 years at baseline in the Boston Puerto Rican Health and San Juan Overweight Adult Longitudinal Studies. We used multivariable Poisson regression models to examine associations between baseline concentrations of metabolites and incident T2D and prediabetes. Cohort-specific estimates were combined using inverse-variance weighted fixed-effects meta-analyses. A cluster of 13 metabolites of branched chain amino acids (BCAA), and aromatic amino acid metabolism (pooled IRR = 1.87, 95% CI: 1.28; 2.73), and a cell membrane component metabolite cluster (pooled IRR = 1.54, 95% CI: 1.04; 2.27) were associated with a higher risk of incident T2D. When the metabolites were tested individually, in combined analysis, 5 metabolites involved in BCAA metabolism were associated with incident T2D. These findings highlight potential prognostic biomarkers to identify Puerto Rican adults who may be at high risk for diabetes. Future studies should examine whether diet and lifestyle can modify the associations between these metabolites and progression to T2D.

Funder

National Institutes of Health

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference45 articles.

1. Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000–2019,2020

2. Global Diabetes Compact Https://Www.Who.Int/Initiatives/the-Who-Global-Diabetes-Compact

3. Precision nutrition for prevention and management of type 2 diabetes

4. Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies

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