Author:
Katsnelson Boris A.,Chernyshov Ivan N.,Solovyeva Svetlana N.,Minigalieva Ilzira A.,Gurvich Vladimir B.,Valamina Irene E.,Makeyev Oleg H.,Sahautdinova Renata R.,Privalova Larisa I.,Tsaregorodtseva Anastasia E.,Korotkov Artem V.,Shuman Eugene A.,Panov Vladimir G.,Sutunkova Marina P.
Abstract
Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
6 articles.
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