Strong Cumulative Evidence of Associations of 6 Single Nucleotide Polymorphisms with Ovarian Cancer Risk: An Umbrella Review
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Published:2023-03-03
Issue:5
Volume:12
Page:2025
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Huo Ying-Jun123, Li Xiao-Ying123, Zhang Meng123, Gao Chang123, Xiao Qian1, Zhao Yu-Hong123, Gao Song4, Gong Ting-Ting4, Wu Qi-Jun1234ORCID
Affiliation:
1. Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang 110004, China 2. Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang 110004, China 3. Key Laboratory of Precision Medical Research on Major Chronic Disease, Shenyang 110004, China 4. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36, San Hao Street, Shenyang 110004, China
Abstract
Background: An increasing number of studies have reported associations between single nucleotide polymorphisms (SNPs) and ovarian cancer (OC) risk. However, some of the findings were inconsistent. The objective of this umbrella review was to evaluate the associations comprehensively and quantitatively. Methods: The protocol of this review was registered in PROSPERO (No. CRD42022332222). We searched the PubMed, Web of Science, and Embase databases to identify related systematic reviews and meta-analyses from inception to 15 October 2021. In addition to estimating the summary effect size by using fixed and random effects models and calculating the 95% prediction interval, we evaluated the cumulative evidence for associations with nominally statistical significance based on the Venice criteria and false positive report probability (FPRP). Results: Forty articles were included in this umbrella review, which referred to a total of 54 SNPs. The median number of original studies per meta-analysis was four, while the median number of total subjects was 3455. All included articles had greater than moderate methodological quality. A total of 18 SNPs were nominally statistically associated with OC risk; 6 SNPs (8 genetic models), 5 SNPs (7 genetic models), and 16 SNPs (25 genetic models) were identified as strong, moderate, and weak cumulative evidence, respectively. Conclusion: This umbrella review revealed associations between SNPs and OC risk and suggested strong cumulative evidence of associations of six SNPs (eight genetic models) with OC risk.
Funder
Natural Science Foundation of China LiaoNing Revitalization Talents Program Shenyang High-Level Innovative Talents Support Program 345 Talent Project of Shengjing Hospital of China Medical University Clinical Research Cultivation Project of Shengjing Hospital JieBangGuaShuai Project of Liaoning Province
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