Genotoxic Aspects of Psychoactive Substances

Abstract

Exposure to psychoactive substances is undoubtedly a serious public health issue that should be carefully analyzed from different perspectives. Regarding the types of toxic effects inflicted by these xenobiotics, it is already known that many of the common abused psychoactives have shown positive genotoxicity findings in complementary genetic toxicology assays. Nevertheless, while there are several experimental articles and reviews on this topic, it is also clear that additional information, particularly mechanistic studies, is still needed. This article addresses these issues, pointing out some aspects of the potential genotoxicity of psychoactive substances that should be further explored, and suggests some possible approaches that could be valuable in future toxicological studies.