Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production

Author:

Chou Yu-Chieh1,Sung Ting-Hsuan2,Hou Shi-Jing3,Khumsupan Darin4ORCID,Santoso Shella Permatasari56,Cheng Kuan-Chen2378ORCID,Lin Shin-Ping13910ORCID

Affiliation:

1. Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan

2. Institute of Food Science and Technology, National Taiwan University, 1 Roosevelt Rd., Sec. 4, Taipei 10617, Taiwan

3. School of Food Safety, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan

4. Institute of Biotechnology, National Taiwan University, 1 Roosevelt Rd., Sec. 4, Taipei 10617, Taiwan

5. Department of Chemical Engineering, Widya Mandala Surabaya Catholic University, Kalijudan 37, Surabaya 60114, Indonesia

6. Collaborative Research Center for Zero Waste and Sustainability, Jl. Kalijudan 37, Surabaya 60114, Indonesia

7. Department of Optometry, Asia University, 500 Lioufeng Rd., Wufeng, Taichung 41354, Taiwan

8. Department of Medical Research, China Medical University Hospital, China Medical University, 91, Hsueh-Shih Road, Taichung 40402, Taiwan

9. Research Center of Biomedical Device, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan

10. TMU Research Center for Digestive Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan

Abstract

Cordyceps militaris is a valuable medicinal fungus which has been widely used as a traditional medicine in East Asia. Compared to the well-known medicinal fungus C. sinensis, C. militaris can produce similar fermented metabolites with various biological activities, but it requires a shorter culture time and simpler culture conditions, and therefore, it has attracted increasing attention in recent years. The purpose of this review was to organize the current studies regarding metabolite production from C. militaris relative to their biological functions. We combined findings of metabolite production to correlate with different fermentation modes to obtain a full view of production processes used to yield the product. While research on C. militaris fermentation is not uncommon to date, its high value still highlights the importance of developing more modern fermentation processes for industrial production.

Publisher

MDPI AG

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