Affiliation:
1. Department for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di Val Cannuta, 247, 00166 Rome, Italy
2. IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166 Rome, Italy
Abstract
Vitamin D plays a crucial role in the human body, influencing a wide range of physiological processes from bone health to immune function. The complex biochemical pathways involved in the synthesis, metabolism, and action of Vitamin D are explored, emphasizing its importance in nutrition and food technology. This review also investigates the regulatory mechanisms that control Vitamin D metabolism and its systemic effects on calcium homeostasis, cell proliferation, differentiation, and immune modulation. The role of Vitamin D3 in regulating blood pressure and atherosclerosis in the onset of cardiovascular disorders is discussed. Given the importance of Vitamin D in food science and technology, the regulatory mechanisms that control Vitamin D metabolism and its systemic effects on calcium homeostasis are also investigated, integrating innovative approaches and advanced technologies to improve human health through nutrition. Additionally, the review assesses the influence of food processing on Vitamin D levels and discusses cutting-edge technologies as innovative strategies to mitigate Vitamin D loss during food processing. This comprehensive exploration aims to improve our understanding of the biochemical pathways of Vitamin D and its relevance to food science, contributing to the development of new strategies for food fortification and the promotion of optimal health through diet.
Reference135 articles.
1. Vitamin D: Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites;Janousek;Crit. Rev. Clin. Lab. Sci.,2022
2. Vitamin D Deficiency and Cardiovascular Diseases: The Causality or Association?;Cheng;Int. J. Gerontol.,2018
3. Studies on experimental rickets: XXI. an experimental demonstration of the existence of a vitamin which promotes calcium deposition;McCollum;J. Biol. Chem.,1922
4. The Role of Vitamin D in Health and Disease: A Narrative Review on the Mechanisms Linking Vitamin D with Disease and the Effects of Supplementation;Rebelos;Drugs,2023
5. Vitamin D and Phosphate Interactions in Health and Disease;Akimbekov;Phosphate Metab. Physiol. Toxic.,2022