Monitoring Perfusion Index in Patients Presenting to the Emergency Department Due to Drug Use

Author:

Grigorasi Gabriela Raluca12ORCID,Corlade-Andrei Mihaela12,Ciumanghel Irina12,Sova Ivona2,Blaga Teofil2,Carp Claudiu2,Cimpoesu Diana12

Affiliation:

1. Faculty of Medicine, University of Medicine and Pharmacy “Gr. T. Popa”, 700115 Iasi, Romania

2. Emergency University Department “St. Spiridon” Hospital, 700111 Iasi, Romania

Abstract

(1) Background: The perfusion index (PI) represents the ratio between pulsatile blood flow and non-pulsatile blood flow in the peripheral tissue. (2) We aimed to investigate the blood pressure perfusion of tissues and organs in ethnobotanical, synthetic cannabinoid and cannabis derivative consumers through the value of perfusion index. (3) Results: The patients enrolled were divided into two groups: group A, which included all patients who presented in the ED within the first three hours after consumption, and group B, which included those patients who presented more than three hours and up to 12 h after drug consumption. The average values of the PI in the case of group A/group B were 1.51 ± 1.07/4.55 ± 3.66. Statistically significant correlations in both groups were recorded between the drug intake ED admission, respiratory rate, peripheral blood oxygen saturation and tissue perfusion index (p < 0.001). The average value of the PI measured in group A was significantly lower compared to that measured in patients in group B. Therefore, we concluded that the perfusion of peripheral organs and tissues was lower in the first 3 h after drug administration. (4) Conclusions: PI plays an important role in the early detection of impaired organ perfusion and in monitoring tissue hypoxia. A decreased PI value may be an early indication of decreased perfusion organ damage.

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

Reference17 articles.

1. Cardiovascular effects of marijuana and synthetic cannabinoids: The good, the bad, and the ugly;Pacher;Nat. Rev. Cardiol.,2018

2. Cytotoxicity of synthetic cannabinoids found in “Spice” products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line;Tomiyama;Toxicol. Lett.,2011

3. Pharmacokinetics and Pharmacodynamics of Cannabinoids;Grotenhermen;Clin. Pharmacokinet.,2003

4. Senate Committee on Public Health and Welfare (2010, June 02). State of Kansas Supplemental Note on Senate Bill No. 348. Session of 2010. Available online: http://www.kslegislature.org/supplemental/2010/SN0348.pdf.

5. (2022, November 24). Guide Clinical Applications of Perfusion Index-Massimo. (2007, Massimo Corporation, White Papers, lab3410f). Available online: https://www.masimo.co.uk/siteassets/uk/documents/pdf/clinical.

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