Laboratory Findings and Clinical Outcomes of ICU-admitted COVID-19 Patients: A Retrospective Assessment of Particularities Identified among Romanian Minorities
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Published:2023-01-21
Issue:2
Volume:13
Page:195
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ISSN:2075-4426
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Container-title:Journal of Personalized Medicine
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language:en
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Short-container-title:JPM
Author:
Mocanu Alexandra1, Lazureanu Voichita Elena1, Laza Ruxandra1, Marinescu Adelina Raluca1, Cut Talida Georgiana1ORCID, Sincaru Suzana-Vasilica2, Marza Adina Maria3ORCID, Popescu Irina-Maria4, Herlo Lucian-Flavius5, Nelson-Twakor Andreea6, Rivis Mircea7ORCID, Bratosinand Felix1, Porosnicu Tamara Mirela8, Mederle Alexandru Ovidiu3ORCID
Affiliation:
1. Department XIII, Discipline of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, Romania 2. Emergency Institute for Cardiovascular Diseases and Transplantation, Strada Gheorghe Maricescu, 540327 Targu Mures, Romania 3. Department of Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania 4. Department XIII, Discipline of Epidemiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania 5. Department of Surgery, Ineu City Hospital, Republicii Street 2, 315300 Arad, Romania 6. Faculty of Medicine and Pharmacy, “Ovidius” University of Constanta, 900527 Constanta, Romania 7. Department of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania 8. Intensive Care Unit, “Victor Babes” Hospital for Infectious Disease and Pneumology, Strada Gheorghe Adam 13, 300041 Timisoara, Romania
Abstract
The Roma population accounts for over 3% (approximately 10 to 15 million) of Romania’s permanent population, and it represents one of Europe’s most impoverished populations. Due to poverty and unemployment, Romania’s Roma minority may have diminished access to healthcare and preventive medicine. The limited existing evidence suggests that the European Roma group has been at a higher risk of becoming ill and dying during the pandemic owing to their lifestyle choices, socioeconomic circumstances, and genetic pathophysiological traits. As a result, the purpose of the present research was to investigate the link between the inflammatory markers implicated and the clinical progression of COVID-19 in Roma patients who were brought to the intensive care unit. We considered 71 Roma patients admitted to the ICU with SARS-CoV-2 infection and 213 controls from the general population with the same inclusion criteria. The body mass index of patients was statistically significantly higher among Roma patients, with more than 57% being overweight, compared with 40.7% in the control group. Frequent smoking was more prevalent in patients of Roma ethnicity admitted to the ICU and the number of comorbidities. We observed a significantly higher proportion of severe imaging features at admission in the group of cases, although this difference may have been associated with the higher prevalence of smoking in this group. The mean duration of hospitalization was longer by 1.8 days than the control group. Elevated ESR levels were observed in 54.0% of Roma patients at admission, compared with 38.9% in the control group. Similarly, 47.6% of them had elevated CRP levels. IL-6 increased significantly at the time of ICU admission, similarly to the significant rise in the CRP levels, compared with the general population. However, the proportion of intubated patients and mortality did not differ significantly. On multivariate analysis, the Roma ethnicity significantly influenced the CRP (β = 1.93, p-value = 0.020) and IL-6 (β = 1.85, p-value = 0.044). It is necessary to plan different healthcare strategies aimed at special populations, such as the Roma ethnicity, to prevent the reduced disparities presented in in this study.
Subject
Medicine (miscellaneous)
Reference47 articles.
1. Mattoo, S.U., Kim, S.J., Ahn, D.G., and Myoung, J. (2022). Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin. Viruses, 14. 2. Marincu, I., Bratosin, F., Vidican, I., Bostanaru, A.-C., Frent, S., Cerbu, B., Turaiche, M., Tirnea, L., and Timircan, M. (2021). Predictive Value of Comorbid Conditions for COVID-19 Mortality. J. Clin. Med., 10. 3. Timircan, M., Bratosin, F., Vidican, I., Suciu, O., Tirnea, L., Avram, V., and Marincu, I. (2021). Exploring Pregnancy Outcomes Associated with SARS-CoV-2 Infection. Medicina, 57. 4. Understanding the pathophysiology of typical acute respiratory distress syndrome and severe COVID-19;Ball;Expert Rev. Respir. Med.,2022 5. Stoicescu, E.R., Manolescu, D.L., Iacob, R., Cerbu, S., Dima, M., Iacob, E.R., Ciuca, I.M., Oancea, C., and Iacob, D. (2022). The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms. J. Clin. Med., 11.
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