Phylogenetic and Genetic Variation Analysis of Porcine Epidemic Diarrhea Virus in East Central China during 2020

Phylogenetic and Genetic Variation Analysis of Porcine Epidemic Diarrhea Virus in East Central China during 2020–2023

Published:2024-07-26 Issue:15 Volume:14 Page:2185
ISSN:2076-2615
Container-title:Animals
language:en
Short-container-title:Animals

Author:

Sun Liumei¹²^ORCID,Li Duo¹²,Yan Caijie¹²,Wu Chengyue¹²^ORCID,Han Feng¹²,Bo Zongyi³⁴^ORCID,Shen Manman¹²^ORCID,Sun Yiwei¹²,Wang Liyan¹²,Zheng Haoqin¹²,Wang Mengdong¹²,Zhang Zhendong¹²³⁴

Affiliation:

1. Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China

2. Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Scientific Research Center, Chinese Academy of Agricultural Sciences, Zhenjiang 212100, China

3. Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China

4. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China

Abstract

Porcine epidemic diarrhea virus (PEDV) is a major causative pathogen of a highly contagious, acute enteric viral disease. This study evaluated the emergence of nine variants in Jiangsu and Anhui provinces of China from 2020 to 2023. S gene-based phylogenetic analysis indicated that three variants belong to the G1c subgroup, while the other six strains are clustered within the G2c subgroup. Recombination analyses supported that three variants of the G1c subgroup were likely derived from recombination of parental variants FR0012014 and a donor variant AJ1102. In addition, there are novel mutations on amino acid 141–148 and these likely resulted in changes in antigenicity in the three variants. These results illustrated that the study provides novel insights into the epidemiology, evolution, and transmission of PEDV in China.

Funder

Natural Science Foundation of Jiangsu Province

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-2615/14/15/2185/pdf

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