Affiliation:
1. Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China
2. The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510260, China
3. Chongqing Jiangbei Mental Health Center, Chongqing 510000, China
Abstract
Objectives: As a new physical therapeutic technique, magnetic seizure therapy (MST) has established efficacy in the treatment of depression with few cognitive side effects, and thus appears to be a potential alternative to electroconvulsive therapy (ECT). The findings of randomized controlled trials (RCTs) examining the efficacy and safety of MST versus ECT for depression are inconsistent. This systematic review of RCTs was designed with the aim of assessing the safety and efficacy of MST versus ECT for patients with depression. Methods: The WanFang, Chinese Journal Net (CNKI), EMBASE, PubMed, Cochrane Library, and PsycINFO databases were systematically searched by three independent investigators, from their inceptions to July 24, 2021. Results: In total, four RCTs (n = 86) were included and analyzed. Meta-analyses of study-defined response (risk ratio (RR) = 1.36; 95% CI = 0.78 to 2.36; p = 0.28; I2 = 0%), study-defined remission (RR = 1.17; 95% CI = 0.61 to 2.23; p = 0.64; I2 = 0%), and the improvement in depressive symptoms (standardized mean difference (SMD) = 0.21; 95% CI = −0.29 to 0.71; p = 0.42; I2 = 0%) did not present significant differences between MST and ECT. Three RCTs evaluated the cognitive effects of MST compared with ECT using different cognitive measuring tools, but with mixed findings. Only two RCTs reported adverse drug reactions (ADRs), but these lacked specific data. Only one RCT reported discontinuation due to any reason. Conclusions: This preliminary study suggests that MST appears to have a similar antidepressant effect as ECT for depression, but mixed findings on adverse cognitive effects were reported.
Funder
Science and Technology Planning Project of Liwan District of Guangzhou
National Natural Science Foundation of China
Scientific Research Project of Guangzhou Bureau of Education
Science and Technology Program Project of Guangzhou
Guangzhou Health Science and Technology Project
Guangzhou Science and Technology Project of Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine
China International Medical Exchange Foundation
Guangzhou Clinical Characteristic Technology Project
Guangdong Hospital Association
Sanming Project of Medicine in Shenzhen
Cited by
3 articles.
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