Poly(methacrylic Acid)-Cellulose Brushes as Anticancer Porphyrazine Carrier

Author:

Krasnopeeva Elena L.,Melenevskaya Elena Yu.,Klapshina Larisa G.ORCID,Shilyagina Natalia Yu.,Balalaeva Irina V.ORCID,Smirnov Nikolay N.,Smirnov Michael A.ORCID,Yakimansky Alexander V.

Abstract

The prospective strategy for treatment of cancer is based on the application of nano-sized macromolecular carriers, which are able penetrate inside and can be accumulated within tumor tissue. In this work graft copolymers of cellulose and poly(methacrylic acid) has been prepared and tested as a nanocontainers for the delivery of drug to tumor. For this purpose, two derivatives of porphyrazine suitable for photodynamic cancer therapy were loaded into prepared polymer brush. Fluorescence imaging was applied for monitoring of accumulation of porphyrazine in the CT26 murine colon carcinoma. The selective accumulation of cellulose brush loaded with porphyrazine in tumor was demonstrated by fluorescence intensity contrast between the tumor area and normal tissues. The tumor growth rate after photodynamic therapy were assessed and inhibition of its growth was revealed.

Funder

Ministry of Education and Science of the Russian Federation

Publisher

MDPI AG

Subject

General Materials Science,General Chemical Engineering

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