Abstract
The exposure to different substances present in the environment can affect the ability of the human body to maintain glucose homeostasis. Some review studies summarized the current evidence about the relationships between environment and insulin resistance or beta-cell dysfunction. Instead, no reviews focused on the relationships between the environment and the alpha cell, although in recent years clear indications have emerged for the pivotal role of the alpha cell in glucose regulation. Thus, the aim of this review was to analyze the studies about the effects of chemical, biological, and physical environmental factors on the alpha cell. Notably, we found studies focusing on the effects of different categories of compounds, including air pollutants, compounds of known toxicity present in common objects, pharmacological agents, and compounds possibly present in food, plus studies on the effects of physical factors (mainly heat exposure). However, the overall number of relevant studies was limited, especially when compared to studies related to the environment and insulin sensitivity or beta-cell function. In our opinion, this was likely due to the underestimation of the alpha-cell role in glucose homeostasis, but since such a role has recently emerged with increasing strength, we expect several new studies about the environment and alpha-cell in the near future.
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference126 articles.
1. Exposomic Determinants of Immune-Mediated Diseases: Special Focus on Type 1 Diabetes, Celiac Disease, Asthma, and Allergies: The HEDIMED Project Approach;Laiho;Environ. Epidemiol.,2022
2. Zorena, K., Michalska, M., Kurpas, M., Jaskulak, M., Murawska, A., and Rostami, S. (2022). Environmental Factors and the Risk of Developing Type 1 Diabetes-Old Disease and New Data. Biology, 11.
3. Environmental Triggering of Type 1 Diabetes Autoimmunity;Houeiss;Front. Endocrinol.,2022
4. Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality;Quinn;Front. Immunol.,2021
5. Current Understandings of the Pathogenesis of Type 1 Diabetes: Genetics to Environment;Giwa;World J. Diabetes,2020
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献