Abstract
Adults with cardiovascular disease and heart failure are at higher risk of cognitive decline. Cerebral hypoperfusion appears to be a significant contributor, which can result from vascular dysfunction and impairment of cerebral blood flow regulation. In contrast, higher cardiorespiratory fitness shows protection against brain atrophy, reductions in cerebral blood flow, and cognitive decline. Given that high intensity interval training (HIIT) has been shown to be a potent stimulus for improving cardiorespiratory fitness and peripheral vascular function, its utility for improving cognitive aging is an important area of research. This article will review the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more optimal stimulus for improving cognitive aging in this population.
Funder
National Institute on Health
Subject
Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health
Reference131 articles.
1. Mild cognitive impairment as a diagnostic entity;Petersen;J. Intern. Med.,2004
2. Prince, M., Wimo, A., Guerchet, M., Ali, G.C., Wu, Y.T., and Prima, M. (2015). World Alzheimer Report 2015—The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends, Alzheimer’s Disease International.
3. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease;Albert;Alzheimers Dement.,2011
4. Potential for primary prevention of Alzheimer’s disease: An analysis of population-based data;Norton;Lancet Neurol.,2014
5. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015;Roth;J. Am. Coll. Cardiol.,2017