Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties-Reference-Cited by-同舟云学术

Gamma, E-Beam and X-ray Irradiations on PE/EVOH/PE Multilayer Film: An Industrial Point of View Regarding the Impact on Mechanical Properties

Published:2023-06-24 Issue:13 Volume:15 Page:2799
ISSN:2073-4360
Container-title:Polymers
language:en
Short-container-title:Polymers

Author:

Girard-Perier Nina¹^ORCID,Marque Sylvain R. A.²,Dupuy Nathalie³^ORCID,Krieguer Blanche¹²³,Dorey Samuel¹^ORCID

Affiliation:

1. Sartorius Stedim FMT S.A.S, Z.I. Les Paluds, Avenue de Jouques CS91051, CEDEX, 13781 Aubagne, France

2. Aix Marseille Univ, CNRS, ICR, Case 551, 13397 Marseille, France

3. Aix Marseille Univ, Avignon Université, CNRS, IRD, IMBE, 13013 Marseille, France

Abstract

X-ray and electron-beam (E-beam) sterilization technologies were assessed to supplement gamma sterilization, the most common radiation technology used today for biopharmaceutical product sterilization. The mechanical properties of a PE/EVOH/PE film were studied using tensile tests and dynamical mechanical analysis after each irradiation technology (i.e., gamma, electron beam and X-ray irradiations). The effects of each irradiation were compared using two statistical methods. The results indicate that the three irradiation technologies induce no difference in mechanical properties in the investigated dose range for this material.

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

Link

https://www.mdpi.com/2073-4360/15/13/2799/pdf

Reference50 articles.

1. The Maturation of Single-Use Applications;Vogel;BioProcess Int.,2012

2. Mahajan, E., Lye, G., and Eibl-Schindler, R. (2023, March 01). Bridging Polymer Science to Biotechnology Applications: A Single-Use Technology Conference Report. Available online: https://bioprocessintl.com/manufacturing/single-use/bridging-polymer-science-to-biotechnology-applications-a-single-use-technology-conference-report/.

3. Scott, C. (2023, March 01). Downstream Disposables: The Latest Single-Use Solutions for Downstream Processing. Available online: https://bioprocessintl.com/downstream-processing/downstream-single-use-technologies/downstream-processing-single-use-solutions/.

4. (2023, March 01). Guide to Irradiation and Sterilization Validation of Single-Use Bioprocess Systems. Available online: https://bioprocessintl.com/upstream-processing/upstream-single-use-technologies/guide-to-irradiation-and-sterilization-validation-of-single-use-bioprocess-systems-183975/.

5. (2006). Sterilization of HealthCare Products-Radiation-Part 1: Requirements for Development, Validation and Routine Control of a Sterilization Process for MedicalDevices (Standard No. ISO 11137-1).

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Shape-Memory Effect of 4D-Printed Gamma-Irradiated Low-Density Polyethylene;Crystals;2024-08-10