Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds-Reference-Cited by-同舟云学术

Effect of Nitrogen Arc Discharge Plasma Treatment on Physicochemical Properties and Biocompatibility of PLA-Based Scaffolds

Published:2023-08-11 Issue:16 Volume:15 Page:3381
ISSN:2073-4360
Container-title:Polymers
language:en
Short-container-title:Polymers

Author:

Laput Olesya A.¹,Vasenina Irina V.²^ORCID,Korzhova Alena G.¹,Bryuzgina Anastasia A.¹,Khomutova Ulyana V.¹,Tuyakova Sitora G.¹,Akhmadeev Yuriy H.³^ORCID,Shugurov Vladimir V.³,Bolbasov Evgeny N.⁴^ORCID,Tverdokhlebov Sergei I.⁴^ORCID,Chernyavskii Aleksandr V.⁵,Kurzina Irina A.¹^ORCID

Affiliation:

1. Chemical Department, National Research Tomsk State University, 36 Lenin Ave., Tomsk 634050, Russia

2. P.N. Lebedev Physical Institute, 53 Leninsky Prospekt, Moscow 119333, Russia

3. Institute of High Current Electronics, 2/3 Akademichesky Ave., Tomsk 634055, Russia

4. Scientific and Educational Center Named after B.P. Weinberg, National Research Tomsk Polytechnic University, 30 Lenin Ave., Tomsk 634050, Russia

5. Nanocenter MIREA, MIREA—Russian Technological University, 78 Vernadskogo Ave., Moscow 119454, Russia

Abstract

The effect of low-temperature arc discharge plasma treatment in a nitrogen atmosphere on the modification of the physicochemical properties of PLA-based scaffolds was studied. In addition, the cellular-mediated immune response when macrophages of three donors interact with the modified surfaces of PLA-based scaffolds was investigated. PLA surface carbonization, accompanied by a carbon atomic concentration increase, was revealed to occur because of plasma treatment. Nitrogen plasma significantly influenced the PLA wettability characteristics, namely, the hydrophilicity and lipophilicity were improved, as well as the surface energy being raised. The viability of cells in the presence of the plasma-modified PLA scaffolds was evaluated to be higher than that of the initial cells.

Funder

Ministry of Sciences and Higher Education of the Russian Federation

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

Link

https://www.mdpi.com/2073-4360/15/16/3381/pdf

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