1. Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal
2. Laboratory for Evidence-Based Sciences and Precision Dentistry (LACBE–MDP), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal
3. Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal
4. Institute of Experimental Pathology, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal
5. Clinical Academic Center of Coimbra (CACC), 3000-354 Coimbra, Portugal
6. Center for Innovative Biomedicine and Biotecnhology (CIBB), 3000-354 Coimbra, Portugal
7. Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal
8. Institute of Orthodontics, Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal
9. Laboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal