Laminar Biomaterial Composite of PVA Cryogel with Amnion as Potential Wound Dressing

Author:

Otulakowski Łukasz1,Klama-Baryła Agnieszka2,Celny Anna1ORCID,Kasprów Maciej1,Hercog Anna1,Godzierz Marcin1ORCID,Sitkowska Anna2,Kadłubowski Sławomir3,Jaworska Magdalena4,Chmielik Ewa4,Trzebicka Barbara1,Utrata-Wesołek Alicja1ORCID

Affiliation:

1. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Skłodowskiej 34, 41-819 Zabrze, Poland

2. Dr. Stanislaw Sakiel Center for Burn Treatment, 2 Jana Pawla II St., 41-100 Siemianowice Śląskie, Poland

3. Institute of Applied Radiation Chemistry, Chemistry Faculty, Lodz University of Technology, Wróblewskiego 15, 90-924 Łódź, Poland

4. Tumor Pathology Department, Maria Skłodowska-Curie National Research Institute of Oncology Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-102 Gliwice, Poland

Abstract

Gel dressings, composed of polymers both natural and synthetic, are successfully used in the treatment of burn wounds. They protect the burn wound site against adverse external factors, ensure an adequate level of tissue hydration, have soothing and pain-relieving properties, and also support the healing process and reduce the risk of pathological scars. Another promising material that can be used in the wound-healing process is an amnion membrane. Due to its valuable properties such as protecting the body against bacterial infections and permeability to nutrition, it has found usage in different brands of medicine. In this work, we have combined the beneficial properties of hydrogels and amnion in order to make the laminar dressing that may serve for wound healing. For that purpose, the physically crosslinked cryogel of poly(vinyl alcohol) (PVA) was covered with an amnion membrane. Subsequently, gamma irradiation was performed, leading to the simultaneous internal crosslinking of the hydrogel, its permanent bonding with the amnion, and dressing sterilization. The physicochemical properties of the dressing including gel fraction, swelling, and hardness were studied. Biological tests such as the MTT assay, antimicrobial activity, and histopathological examination confirmed that the obtained material constituted a promising candidate for further, more in-depth studies aiming at wound dressing application.

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

Reference55 articles.

1. Modern wound care—Practical aspects of non-interventional topical treatment of patients with chronic wounds;Dissemond;JDDG J. Dtsch. Dermatol. Ges.,2014

2. Hydrogels for biomedical applications;Hoffman;Adv. Drug Deliv. Rev.,2012

3. Synthetic Hydrogels for Biomedical Applications;Andrade;Hydrogels for Medical and Related Applications,1976

4. Okay, O. (2014). Polymeric Cryogels: Macroporous Gels with Remarkable Properties, Springer International Publishing.

5. Hassan, C.M., and Peppas, N.A. (2000). Biopolymers · PVA Hydrogels, Anionic Polymerisation Nanocomposites, Springer.

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