Gelatin-Functionalized Carbon Nanotubes Loaded with Cisplatin for Anti-Cancer Therapy

Author:

Li Rong123,Bao Zhenfei123,Wang Pei123,Deng Yunyun123,Fan Junping123,Zhu Xin123,Xia Xinyu123,Song Yiming123,Yao Haiyan123,Li Dongfang123

Affiliation:

1. School of Stomatology, Nanchang University, Nanchang 330006, China

2. The Key Laboratory of Oral Biomedicine, Jiangxi Province, Nanchang 330006, China

3. Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang 330006, China

Abstract

Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug’s high concentration in the tumor-weak acid environment. These flaws of cisplatin restrict its use in clinical applications. Therefore, a pH-responsive carbon nanotube-modified nano-drug delivery system (CNTs/Gel/Cp) was constructed in this study using gelatin (Gel)-modified carbon nanotubes (CNTs/Gel) loaded with cisplatin to release drugs precisely and slowly, preventing premature inactivation and maintaining an effective concentration. When MCp:MCNTs/Gel = 1:1, the drug reaches the highest loading rate and entrapment efficiency. To achieve the sustained-release effect, CNTs/Gel/Cp can release the medicine steadily for a long time in a pH environment of 6.0. Additionally, CNTs/Gel/Cp display antitumor properties comparable to cisplatin in a manner that varies with the dosage administered. These findings indicate that CNTs/Gel/Cp have an effective, sustained release of cisplatin and a good antitumor effect, providing a theoretical and experimental basis for the clinical application of modified carbon nanotubes (CNTs) as a new drug delivery system.

Funder

National Natural Science Foundation of China

Jiangxi Provincial Natural Science Foundation

Science and Technology Program Project of the Health Commission of Jiangxi Province

Graduate Innovation Special Fund Project of Jiangxi Province

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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