Affiliation:
1. Institute of Chemical Problems, Karagandy University of the Name of Academician E.A. Buketov, Karaganda City 100028, Kazakhstan
Abstract
The aim of this study was to create nanoparticles of human serum albumin immobilized with anti-TB drugs (rifampicin, isoniazid) using the desolvation method. Central Composite Design (CCD) was applied to study the effect of albumin, urea, L-cysteine, rifampicin and isoniazid concentration on particle size, polydispersity and loading degree of the drugs. The optimized nanoparticles were spherical in shape with an average particle size of 216.7 ± 3.7 nm and polydispersity of 0.286 ± 4.9. The loading degree of rifampicin and isoniazid in the optimized nanoparticles were 44% and 27%, respectively. The obtained nanoparticles were examined by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC); the results showed the absence of drug–polymer interactions. The drug release from the polymer matrix was studied using dialysis membranes.
Funder
Ministry of Education and Science of the Republic of Kazakhstan
Subject
Polymers and Plastics,General Chemistry
Reference49 articles.
1. World Health Organization (2022). Global Tuberculosis Report 2022, Licence: CC BY-NC-SA 3.0 IGO.
2. Development and In Vitro Release of Isoniazid and Rifampicin-Loaded Bovine Serum Albumin Nanoparticles;Ge;Med. Sci. Monit.,2018
3. Tuberculosis Treatment and Drug Regimens;Sotgiu;Cold Spring Harb. Perspect. Med.,2015
4. Mazlan, M.K.N., Mohd Tazizi, M.H.D., Ahmad, R., Noh, M.A.A., Bakhtiar, A., Wahab, H.A., and Mohd Gazzali, A. (2021). Antituberculosis Targeted Drug Delivery as a Potential Future Treatment Approach. Antibiotics, 10.
5. Treatment of Isoniazid-Resistant Pulmonary Tuberculosis;Jhun;Tuberc. Respir. Dis.,2020
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