Synthesis and Characterization of Thermoresponsive Chitosan-graft-poly(N-isopropylacrylamide) Copolymers

Author:

Babelyte Migle1,Peciulyte Laura1,Navikaite-Snipaitiene Vesta1,Bendoraitiene Joana1ORCID,Samaryk Volodymyr2,Rutkaite Ramune1

Affiliation:

1. Department of Polymer Chemistry and Technology, Kaunas University of Technology, Radvilenu Rd. 19, 50254 Kaunas, Lithuania

2. Department of Organic Chemistry, Lviv Polytechnic National University, Stepana Bandery St. 14, 79000 Lviv, Ukraine

Abstract

Thermoresponsive chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymers of different composition were synthesized by free-radical polymerization of chitosan (CS) and N-isopropylacrylamide (NIPAAm) in aqueous solution using potassium persulfate (PPS) as an initiator. By changing the molar ratio of CS:NIPAAm from 1:0.25 to 1:10 graft copolymers with a CS backbone and different amounts of PNIPAM side chains were prepared. The chemical structure of the obtained CS-g-PNIPAAm copolymers was confirmed by FTIR and 1H NMR spectroscopy. 1H NMR spectra were also used to calculate the content of attached PNIPAAm side chains. Moreover, the lower critical solution temperature (LCST) behavior of synthesized copolymers was assessed by cloud point, differential scanning calorimetry and particle size measurements. The aqueous solutions of copolymers containing ≥12 molar percent of PNIPAAm side chains demonstrated LCST behavior with the phase separation at around 29.0–32.7 °C. The intensity of thermoresponsiveness depended on the composition of copolymers and increased with increasing content of poly(N-isopropylacrylamide) moieties. The synthesized thermoresponsive chitosan-graft-poly(N-isopropylacrylamide) copolymers could be potentially applied in drug delivery systems or tissue engineering.

Funder

Research Council of Lithuania

Ministry of Education and Science of Ukraine

Lithuanian–Ukrainian Cooperation Programme in the Fields of Research and Technologies

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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