Polysaccharides—Naturally Occurring Immune Modulators

Author:

Murphy Emma J.123ORCID,Fehrenbach Gustavo Waltzer34ORCID,Abidin Ismin Zainol34ORCID,Buckley Ciara34ORCID,Montgomery Therese5,Pogue Robert6,Murray Patrick12,Major Ian34ORCID,Rezoagli Emanuele78ORCID

Affiliation:

1. Shannon Applied Biotechnology Centre, Midwest Campus, Technological University of the Shannon, V94EC5T Limerick, Ireland

2. LIFE–Health and Biosciences Research Institute, Midwest Campus, Technological University of the Shannon, V94EC5T Limerick, Ireland

3. PRISM, Research Institute, Midlands Campus, Technological University of the Shannon, N37 HD68 Athlone, Ireland

4. Applied Polymer Technologies, Midlands Campus, Technological University of the Shannon, N37 HD68 Athlone, Ireland

5. School of Science and Computing, Atlantic Technological University, H91 T8NW Galway, Ireland

6. Universidade Católica de Brasilia, QS 7 LOTE 1-Taguatinga, Brasília 71680-613, DF, Brazil

7. Department of Emergency and Intensive Care, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy

8. School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy

Abstract

The prevention of disease and infection requires immune systems that operate effectively. This is accomplished by the elimination of infections and abnormal cells. Immune or biological therapy treats disease by either stimulating or inhibiting the immune system, dependent upon the circumstances. In plants, animals, and microbes, polysaccharides are abundant biomacromolecules. Due to the intricacy of their structure, polysaccharides may interact with and impact the immune response; hence, they play a crucial role in the treatment of several human illnesses. There is an urgent need for the identification of natural biomolecules that may prevent infection and treat chronic disease. This article addresses some of the naturally occurring polysaccharides of known therapeutic potential that have already been identified. This article also discusses extraction methods and immunological modulatory capabilities.

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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