Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration-Reference-Cited by-同舟云学术

Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration

Published:2023-06-28 Issue:13 Volume:15 Page:2860
ISSN:2073-4360
Container-title:Polymers
language:en
Short-container-title:Polymers

Author:

Dresvyanina Elena N.¹,Tagandurdyyeva Nurjemal A.²^ORCID,Kodolova-Chukhontseva Vera V.²³,Dobrovol’skaya Irina P.³,Kamalov Almaz M.²^ORCID,Nashchekina Yulia A.⁴,Nashchekin Alexey V.⁵^ORCID,Ivanov Alexey G.³^ORCID,Yukina Galina Yu.⁶,Yudin Vladimir E.³

Affiliation:

1. Institute of Textile and Fashion, Saint Petersburg State University of Industrial Technologies and Design, B. Morskaya Str., 18, Saint Petersburg 191186, Russia

2. Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, Russia

3. Institute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, Russia

4. Institute of Cytology Russian Academy of Sciences, Tikhoretsky Ave., 4, Saint Petersburg 194064, Russia

5. Ioffe Institute, Polytekhnicheskaya Str., 26, Saint Petersburg 194021, Russia

6. Pavlov First Saint Petersburg State Medical University, L’va Tolstogo Str. 6-8, Saint Petersburg 197022, Russia

Abstract

This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nanotubes were investigated in this paper. It was shown that introducing 0.5 wt.% of SWCNT into the composite fibers facilitated the formation of a denser fiber structure, resulting in improved strength (σ = 260 MPa) and elastic (E = 14 GPa) characteristics. Additionally, the composite fibers were found to be biocompatible and did not cause significant inflammation or deformation during in vivo studies. A thin layer of connective tissue formed around the fiber.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

Link

https://www.mdpi.com/2073-4360/15/13/2860/pdf

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