Prevalence of Systemic Hypertension and Control of Systolic Blood Pressure in a Cohort of 14 Dogs with Adrenal-Dependent Hypercortisolism during the First Year of Trilostane Treatment or after Adrenalectomy

Author:

García San José Paula1ORCID,Pérez-Alenza María Dolores1,Alonso-Miguel Daniel1ORCID,González Sanz Sandra2,Arenas Bermejo Carolina34

Affiliation:

1. Department of Animal Medicine and Surgery, Veterinary Faculty, Complutense University of Madrid, 28040 Madrid, Spain

2. Veterinary Teaching Hospital Complutense of Madrid, 28040 Madrid, Spain

3. AniCura Hospital Veterinario Valencia Sur, 46460 Valencia, Spain

4. VetCT Teleconsulting, Cambridge CB3 0FA, UK

Abstract

Hypercortisolism in dogs is frequently associated with systemic hypertension (SH). However, there are no studies evaluating the changes in systolic blood pressure (SBP) in dogs with adrenal-dependent hypercortisolism (ADH) during trilostane treatment or after adrenalectomy and their response to antihypertensive treatments. For this reason, the objectives of this study were to evaluate the changes in SBP in dogs with ADH during the first year of trilostane treatment or after adrenalectomy, the relation with clinical control of hypercortisolism and certain laboratory parameters, and the response to antihypertensive drugs. Fourteen dogs newly diagnosed with ADH were prospectively included and evaluated at diagnosis (T0) and 1, 3, 6, and 12 months after (T1, T3, T6, and T12, respectively). Dogs were classified as hypertensive (HT; SBP ≥ 160 mmHg) and non-hypertensive. In HT dogs, benazepril was considered as the first-line drug, and, if necessary, amlodipine was prescribed. The prevalence of SH at T0 was 79%, and it was reduced to 25% at T12. Blood pressure (BP) was not associated with disease control or selected laboratory parameters at any endpoint. Only 22% of dogs with SH needed more than one drug to normalize their SBP. In all dogs surgically treated that were HT at T0, BP normalized at T3.

Publisher

MDPI AG

Subject

General Veterinary,Animal Science and Zoology

Reference48 articles.

1. Feldman, E.C., Nelson, R.W., Reusch, C., and Scott-Moncrieff, J.C. (2015). Canine and Feline Endocrinology, Elsevier Saunders. [4th ed.].

2. Hyperadrenocorticism in Dogs;Ettinger;Textbook of Veterinary Internal Medicine,2017

3. Complications of Cushing’s syndrome: State of the art;Pivonello;Lancet Diabetes Endocrinol.,2016

4. The hypertension of Cushing’s syndrome: Controversies in the pathophysiology and focus on cardiovascular complications;Isidori;J. Hypertens.,2015

5. Hypertension in Cushing’s syndrome;Magiakou;Best Pract. Res. Clin. Endocrinol. Metab.,2006

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