The VEST External Support for Saphenous Vein Grafts in Coronary Surgery: A Review of Randomized Clinical Trials

Author:

Soletti Giovanni Jr.1ORCID,Dell’Aquila Michele1ORCID,Harik Lamia1,Cancelli Gianmarco1,Alzghari Talal1ORCID,Perezgrovas-Olaria Roberto1,Dimagli Arnaldo1,An Kevin R.1,Leith Jordan1,Rossi Camilla Sofia1,Barile Christopher F.1ORCID,Demetres Michelle2,Lau Christopher1,Girardi Leonard N.1,Gaudino Mario1ORCID

Affiliation:

1. Department of Cardiothoracic Surgery, Weill Cornell Medicine, 525 East 68th Street, New York, NY 10021, USA

2. Samuel J. Wood Library and C.V. Starr Biomedical Information Centre, Weill Cornell Medicine, New York, NY 10021, USA

Abstract

Saphenous vein grafts (SVGs) are the most frequently used conduits in coronary artery bypass grafting (CABG), but their higher rate of occlusion compared to arterial conduits remains a concern. Previous studies have shown that SVG failure is mainly driven by intimal hyperplasia, an adaptative response to higher pressures of the arterial circulation. The VESTTM device (Vascular Graft Solutions, Tel Aviv, Israel), an external support designed to mitigate intimal hyperplasia in SVGs, has been tested in few clinical trials (RCTs). Herein, we descriptively evaluated the randomized evidence on the VEST device.

Publisher

MDPI AG

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

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