Preclinical, Multi-Aspect Assessment of the Reliability of a Photoplethysmography-Based Telemonitoring System to Track Cardiovascular Status

Abstract

Telemonitoring systems equipped with photoplethysmography-based contour analysis of the digital arterial volume pulse (DVP) can be optimal tools for remote monitoring of cardiovascular patients; however, the method is known to be sensitive to errors. We aimed to show that DVP analysis is a reliable method to track cardiovascular status. We used our proprietary SCN4ALL telemedicine system and analyzed nine parameters derived from the DVP and its second derivative (SDDVP). First, we assessed the repeatability of system measurements by detecting artificial signals. Then test–retest reliability of human measurements was evaluated in healthy individuals under standardized conditions. The SCN4ALL system analyzed each parameter with high accuracy (coefficients of variation (CVs) < 1%). Test–retest reliability of most parameters (stiffness index, reflection index, left ventricular ejection time index, b/a, heart rate) was satisfactory (CVs < 10%) in healthy individuals. However, aging index and d/a ratio derived from the SDDVP were more variable. Photoplethysmography-based pulse contour analysis is a reliable method to monitor cardiovascular status if measurements are performed with a system of high accuracy. Our results highlighted that SDDVP parameters can be interpreted with limitations due to (patho)physiological variations of the DVP. We recommend the evaluation of these parameters only in measurements where all inflections of SDDVP are detected reliably.