Author:
Teufel Ashley,Ritchie Andrew,Wilke Claus,Liberles David
Abstract
When mutational pressure is weak, the generative process of protein evolution involves explicit probabilities of mutations of different types coupled to their conditional probabilities of fixation dependent on selection. Establishing this mechanistic modeling framework for the detection of selection has been a goal in the field of molecular evolution. Building on a mathematical framework proposed more than a decade ago, numerous methods have been introduced in an attempt to detect and measure selection on protein sequences. In this review, we discuss the structure of the original model, subsequent advances, and the series of assumptions that these models operate under.
Funder
National Institutes of Health
National Science Foundation
Subject
Genetics (clinical),Genetics
Cited by
12 articles.
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