Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020

Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020–2024)

Published:2024-09-03 Issue:9 Volume:9 Page:202
ISSN:2414-6366
Container-title:Tropical Medicine and Infectious Disease
language:en
Short-container-title:TropicalMed

Author:

Ríos-Bracamontes Eder Fernando¹,Mendoza-Cano Oliver²^ORCID,Lugo-Radillo Agustin³,Ortega-Ramírez Ana Daniela⁴^ORCID,Murillo-Zamora Efrén⁵^ORCID

Affiliation:

1. Departamento de Medicina Interna, Hospital General de Zona No. 1, Instituto Mexicano del Seguro Social, Av. Lapislázuli 250, Villa de Álvarez 28984, Mexico

2. Facultad de Ingeniería Civil, Universidad de Colima, km. 9 Carretera Colima-Coquimatlán, Coquimatlán 28400, Mexico

3. CONAHCyT—Facultad de Medicina y Cirugía, Universidad Autónoma Benito Juárez de Oaxaca, Ex Hacienda Aguilera S/N, Carr. a San Felipe del Agua, Oaxaca 68020, Mexico

4. Facultad de Medicina, Universidad de Colima, Av. Universidad 333, Colima 28040, Mexico

5. Unidad de Investigación en Epidemiología Clínica, Instituto Mexicano del Seguro Social, Av. Lapislázuli 250, Villa de Álvarez 28984, Mexico

Abstract

This study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence intervals (CIs), estimated using generalized linear regression models, were used to evaluate the factors associated with all-cause in-hospital mortality risk. The overall case–fatality rate was 17.5 per 1000. In the multiple model, compared to dengue virus (DENV) 1 infections, DENV-2 (RR = 1.81, 95% CI 1.15–2.86) and DENV-3 (RR = 1.87, 95% CI 1.19–2.92) were associated with increased mortality risk. Patient characteristics, such as increasing age (RR = 1.02, 95% CI 1.01–1.03), type 2 diabetes mellitus (RR = 2.07, 95% CI 1.45–2.96), and chronic kidney disease (RR = 3.35, 95% CI 2.03–5.51), were also associated with an increased risk of a fatal outcome. We documented the influence of both the virus and individual susceptibility on mortality risk, underscoring the need for a comprehensive public health strategy for dengue.

Publisher

MDPI AG

Link

https://www.mdpi.com/2414-6366/9/9/202/pdf

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