Surveillance of Soil-Transmitted Helminth Infection in Preschool Child Population: Do Changes in Behavior and Immunological Responses Affect Prevalence?
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Published:2024-01-30
Issue:2
Volume:9
Page:33
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ISSN:2414-6366
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Container-title:Tropical Medicine and Infectious Disease
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language:en
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Short-container-title:TropicalMed
Author:
Adrizain Riyadi1ORCID, Nagari Monika Verena2, Sukandar Hadyana3, Berbudi Afiat4, Setiabudi Djatnika1, Setiabudiawan Budi15ORCID
Affiliation:
1. Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia 2. Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia 3. Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia 4. Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia 5. Faculty of Medicine, President University, Bekasi 17550, Indonesia
Abstract
Soil-transmitted helminths (STHs) persist as a significant global public health issue among neglected tropical diseases (NTDs), particularly in children. STH infection can induce immune responses that affect the course of the disease; if treatment fails, chronic infection can lead to stunting, especially among children aged 24–59 months, which is a vulnerable period for growth and development. We conducted a correlational, cross-sectional data collection study to evaluate the characteristics and association of 25(OH)D, interleukin-5 (IL-5), and interleukin-13 (IL-13) with the prevalence of STH infection in children aged 24–59 months in Bandung District, Indonesia, in October 2019–January 2023. We recruited 694 subjects (401 stunted and 293 normal-height children). The prevalence of STH infection among the stunted and normal-height groups was 5.7% (95% CI: 3.85–8.46%) and 3.4% (95% CI; 1.86–6.17%) (p = 0.156), respectively. The probability of the prevalence of STH infection in children with levels of 25(OH)D, IL-5, and IL-13 below the cut-off point was 6,93 to 16.71 times higher. We found a relationship between IL-5, IL-13, and environmental factors and the prevalence of STH infection in stunted children.
Funder
Padjadjaran University
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,General Immunology and Microbiology
Reference31 articles.
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