Synthesis of 3-Bromo-4-phenylisothiazole-5-carboxylic Acid and 3-Bromoisothiazole-5-carboxylic Acid-Reference-Cited by-同舟云学术

Synthesis of 3-Bromo-4-phenylisothiazole-5-carboxylic Acid and 3-Bromoisothiazole-5-carboxylic Acid

Published:2023-01-17 Issue:1 Volume:2023 Page:M1557
ISSN:1422-8599
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language:en
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Author:

Kalogirou Andreas S.^ORCID,Koutentis Panayiotis A.^ORCID

Abstract

Reactions of 3-bromo-4-phenylisothiazole-5-carboxamide and 3-bromoisothiazole-5-carboxamide with NaNO2 (4 equiv.), in TFA, at ca. 0 °C gave the carboxylic acid products in 99% and 95% yields, respectively. The two compounds were fully characterized.

Funder

Cyprus research promotion foundation

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2023/1/M1557/pdf

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