In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2-Reference-Cited by-同舟云学术

In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2

Published:2023-05-11 Issue:5 Volume:15 Page:1155
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Villalobos-Sánchez Erendira¹^ORCID,García-Ruiz Daniel¹,Camacho-Villegas Tanya A.²^ORCID,Canales-Aguirre Alejandro A.¹^ORCID,Gutiérrez-Ortega Abel¹^ORCID,Muñoz-Medina José E.³^ORCID,Elizondo-Quiroga Darwin E.¹^ORCID

Affiliation:

1. Medical and Pharmaceutical Biotechnology Unit, Center of Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara 44270, Mexico

2. CONACYT, Medical and Pharmaceutical Biotechnology Unit, Center of Research and Assistance in Technology and Design of the State of Jalisco, Guadalajara 44270, Mexico

3. Coordinación de Calidad de Insumos y Laboratorios Especializados, Instituto Mexicano del Seguros Social, México City 27170, Mexico

Abstract

The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (Larrea tridentata) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2.

Funder

CONACYT

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/5/1155/pdf

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