Physicochemical Analysis and Wound Healing Activity of Azadirachta indica (A. Juss) Fruits-Reference-Cited by-同舟云学术

Physicochemical Analysis and Wound Healing Activity of Azadirachta indica (A. Juss) Fruits

Published:2023-06-01 Issue:6 Volume:11 Page:1692
ISSN:2227-9717
Container-title:Processes
language:en
Short-container-title:Processes

Author:

Boukeloua Ahmed¹²,Kouadria Mostefa³,Bendif Hamdi⁴⁵^ORCID,Plavan Gabriel⁶^ORCID,Alsalamah Sulaiman A.⁷,Alghonaim Mohammed I.⁷,Boufahja Fehmi⁷,Abd-Elkader Omar H.⁸^ORCID

Affiliation:

1. Process Engineering Laboratory for Sustainable Development and Health Products, University Constantine 3 Salah Boubnider, Constantine 25000, Algeria

2. Institute of Applied Sciences and Techniques, Faculty of Sciences, University of Oum EL Bouaghi, Oum EL Bouaghi 04000, Algeria

3. Departement NTAA, Faculty of Nature and Life Sciences, Agrobiotechnology and Nutrition Laboratory in Semi-Arid and Arid Zones, Ibn Khaldoun University of Tiaret, Tiaret 14000, Algeria

4. Department of Natural and Life Sciences, Faculty of Sciences, University of M’sila, M’sila 28000, Algeria

5. Laboratory of Ethnobotany and Natural Substances, Department of Natural Sciences, Ecole Normale Superieure (ENS), Algiers 16000, Algeria

6. Department of Biology, Faculty of Biology, “Alexandru Ioan Cuza” University, Bvd. Carol I, No. 20A, 700505 Iasi, Romania

7. Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia

8. Physics & Astronomy Department, Science College, King Saud University, Riyadh 11451, Saudi Arabia

Abstract

(1) Background: The neem tree, Azadirachta indica (A. Juss), is a well-known species used in traditional medicine for the treatment of skin conditions such as irritation, eczema, burns, and wounds. The objective of the current study was to investigate the physicochemical and wound-healing properties of A. indica fruits. (2) Methods: Gas chromatography coupled with mass spectrometry (GC-MS) was used to determine the content of fatty acids and phytosterols, and high-performance liquid chromatography (HPLC) was used to determine the tocopherol content. The wound-healing activity was observed on the backs of six adult male rabbits. (3) Results: The results showed that the plant contained fatty acids, as well as oleic (46.05%), palmitic (23.94%), linoleic (11.39%), and stearic (7.87%) acids. The phytosterols were three major compounds; in decreasing order of importance, they were β-sitosterol (97.26 mg/100 g), campesterol (18.94 mg/100 g), and stigmasterol (12.05 mg/100 g). There were also traces of cholesterol. The neem was a moderate source of vitamin E (α-tocopherol, 14.86 mg/100 g). The hexane extracts showed no acute toxicity and low eye and skin irritability and had reasonable safety and important wound-healing activity. (4) Conclusions: The results confirmed that A. indica is a valuable source of fatty acids, phytosterols, and vitamin E and is efficient in the process of wound healing.

Funder

the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University

Publisher

MDPI AG

Subject

Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering

Link

https://www.mdpi.com/2227-9717/11/6/1692/pdf

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