Affiliation:
1. Institute for Separation and Process Technology, Clausthal University of Technology, Leibnizstraße 15, D-38678 Clausthal-Zellerfeld, Germany
Abstract
The simulated moving bed (SMB) is a well-established, fully continuous process for chromatographic separation of difficult tasks with overlapping peaks, but it is relatively complex. The 1-SMB, which uses only one column but includes residence time zones to preserve concentration profiles, is a simpler semi-continuous alternative. This work examines the possible design of these residence time zones. Simulation studies were conducted to investigate the dependence of process metrics, such as purity, yield, productivity, and eluent consumption, on fluid dynamics. No deterioration in purity was observed, and the other variables remained constant over a wide range of axial dispersion before decreasing sharply. Pilot-scale experiments were conducted with various devices, including coiled flow inverters, eluate recycling devices, packed columns, and tank arrangements, to validate possible apparatus implementations with fluid dynamic measurements. It was demonstrated that the 1-SMB offers similar performance to the 4-SMB, albeit with reduced yield and lower apparatus complexity.
Subject
Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering
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