Affiliation:
1. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
2. Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA
Abstract
Hexokinases (HKs) convert hexose sugars to hexose-6-phosphate, thus trapping them inside cells to meet the synthetic and energetic demands. HKs participate in various standard and altered physiological processes, including cancer, primarily through the reprogramming of cellular metabolism. Four canonical HKs have been identified with different expression patterns across tissues. HKs 1–3 play a role in glucose utilization, whereas HK 4 (glucokinase, GCK) also acts as a glucose sensor. Recently, a novel fifth HK, hexokinase domain containing 1 (HKDC1), has been identified, which plays a role in whole-body glucose utilization and insulin sensitivity. Beyond the metabolic functions, HKDC1 is differentially expressed in many forms of human cancer. This review focuses on the role of HKs, particularly HKDC1, in metabolic reprogramming and cancer progression.
Subject
Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics
Reference167 articles.
1. On the origin of cancer cells;Warburg;Science,1956
2. The Warburg effect: How does it benefit cancer cells?;Liberti;Trends Biochem. Sci.,2016
3. Multiple forms of hexokinase in the rat: Tissue distribution, age dependency, and properties;Katzen;Proc. Natl. Acad. Sci. USA,1965
4. Assignment of hexokinase types 1, 2, 3 (Hk1, 2, 3) and glucokinase (Gck) to rat chromosome band 20q11, 4q34, 17q12 and 14q21 respectively, by in situ hybridization;Sebastian;Cytogenet. Cell Genet.,1997
5. Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function;Wilson;J. Exp. Biol.,2003
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